TABLE 2.
Potential inhibitory B-cell epitopes in DBPII ligand domain
| Peptide | Sequence | Difference in OD value from NI (mean ± SD) | Pa |
|---|---|---|---|
| H1 | FHRDITFRKLYLKRKL | 0.55 ± 0.28 | 0.007 |
| H2 | EGDLLLKLNNYRYN | 0.95 ± 0.15 | 0.008 |
| H3 | DEKAQQRRKQWWNESK | 0.94 ± 0.21 | 0.021 |
| M1 | FCKDIRWSLGDF | 0.66 ± 0.21 | 0.031 |
| M2 | LKGNFIWICKLNVAVN | 0.45 ± 0.07 | 0.032 |
| M3 | PQIYRWIREWGRDYVS | 0.56 ± 0.45 | 0.050 |
| L1 | CIPDRRYQLCMK | 0.46 ± 0.31 | 0.333 |
| L2 | AQIWTAMMYSVK | 0.38 ± 0.26 | 0.333 |
| L3 | MEGIGYSKVVENNL | 0.72 ± 0.24 | 0.343 |
| L4 | DWDCNTKKDVCIPD | 0.58 ± 0.21 | 0.394 |
a
P values were obtained by comparison of average values for the HI and NI peptides using a nonparametric Mann-Whitney test. Differences were considered statistically significant if the P value was <0.05. H1 to H3 are high-inhibition B-cell epitopes, M1 to M3 are moderate-inhibition B-cell epitopes, and L1 to L4 are low-inhibition B-cell epitopes.