FIG. 3.
Kaplan-Meier survival curves for the different posaconazole treatment dosage groups at the high inoculum (2.9 × 106 conidia/animal) (A), mid-inoculum range (6.5 × 105 to 6.8 × 105 conidia/animal) (B), and low inoculum range (7.7 × 104 to 7.8 × 104 conidia/animal) (C). Twice-daily dosing with oral posaconazole (black circles, 6.25 mg/kg; black triangles, 12.5 mg/kg; gray inverted triangles, 25 mg/kg; gray diamonds, 50 mg/kg) was initiated 12 h following intravenous inoculation in neutropenic mice, and values were compared to those for untreated controls (black squares).