TABLE 1.
Fusarium solani kidney tissue fungal burden in mice that received posaconazole as treatment beginning 12 h after inoculationa
| Inoculum (no. of conidia/animal; no. of animals/group) | Median log10 CFU/g in kidneys (range) for group: |
||||
|---|---|---|---|---|---|
| Control | PSC at mg/kg: |
||||
| 6.25 | 12.5 | 25 | 50 | ||
| High (2.9 × 106; 10) | 5.8 (4.9-6.1) | 5.6 (5.1-6.2) | 5.3 (4.7-5.5) | 5.3 (4.8-5.9) | 5.2 (4.4-5.9) |
| Middle (6.5 × 105-6.8 × 105; >20) | 6.1 (3.4-6.4) | 6.0 (4.4-6.5) | 5.8 (4.8-6.5) | 5.6 (2.4-6.4)* | 5.4 (3.7-6.4)* |
| Low (7.7 × 104-7.8 × 104; >20) | 5.3 (3.1-6.3) | 5.0 (2.7-5.9) | 5.1 (1.2-6.2) | 5.0 (1.5-5.9)* | 4.6 (1.2-6.0)* |
a
Median log10 CFU/g values and ranges are reported for each dosage group. P values are reported for posaconazole (PSC) regimens with significant reductions in log10 CFU/g compared to untreated controls (*, P < 0.05).