TABLE 3.
Group (no. of tablets × no. of daily doses) | CQ |
DECQ |
||
---|---|---|---|---|
Cmax (μg/liter) | AUC0-∞ (μg·h/liter) | Cmax (μg/liter) | AUC0-g∞ (μg·h/liter) | |
Nonpregnant (3 × 3) | 376 | 50,028 | 186 | 41,255 |
Pregnant (3 × 3) | 296 (79) | 35,659 (71) | 139 (75) | 23,876 (58) |
Pregnant (4 × 3) | 395 (105) | 47,545 (95) | 185 (100) | 31,835 (77) |
Pregnant (5 × 3) | 494 (131) | 59,431 (119) | 232 (125) | 39,793 (96) |
The numbers in parentheses represent the simulated medians for pregnant subjects expressed as percentages of that for the standard dose of 3 tablets (450 mg CQ base) in 3 daily doses for nonpregnant subjects.