TABLE 2.
MICs of 10 KPC-positive Acinetobacter calcoaceticus-baumannii complex isolates to selected antibiotics
| Test agenta | Range (μg/ml) | MIC (μg/ml) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C1AC9-24 | M2AC9-31 | M3AC9-2 | M3AC9-4 | M3AC9-6 | M3AC9-7 | MC1AC9-26 | MC4AC9-30 | N2AC9-18 | N2AC9-19 | W2AC8-S10d | E. coli ATCC 25922 | P. aeruginosa ATCC 27853 | ||
| CTX | 1-32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 4 | 1 | 16 |
| CAZ | 1-16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | 2 | 1 | 2 |
| FEP | 2-16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 | 2 | 2 | <2 |
| TZP | 8/4-64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | >64/4 | 8/4 | 8/4 | <8/4 |
| DORb | 0.12-2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | 0.12 | 0.12 | 0.5 |
| IPM | 1-8 | 4 | 8/I | >8 | >8 | >8 | >8 | 8 | 8 | >8 | >8 | 1 | 1 | 2 |
| MEM | 1-8 | 4 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | 1 | 1 | <1 |
| CIP | 0.25-2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | 0.25 | 0.25 | 0.25 |
| LVX | 1-8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | 1 | 1 | <1 |
| GEN | 1-8 | >8 | >8 | 2 | >8 | 2 | <1 | 8 | >8 | >8 | >8 | 1 | 1 | <1 |
| AMK | 4-32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 4 | 4 | <4 |
| SXT | 0.5/9.5-4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | >4/76 | 0.5/9/.5 | 0.5/9.5 | >4/76 |
| MIN | 2-16 | 8 | <2 | <2 | 4 | <2 | <2 | <2 | 4 | <2 | <2 | 2 | 2 | 16 |
| TGCc | 0.25-8 | 1 | 1 | 0.5 | 0.25 | 0.5 | 0.5 | 2 | 0.5 | 1 | 2 | <0.25 | 0.25 | 8 |
| CST | 0.25-4 | 1 | 0.5 | 0.5 | 1 | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 1 |
| PMB | 0.25-4 | 0.5 | <0.25 | <0.25 | <0.25 | 0.5 | 0.5 | <0.25 | 0.5 | <0.25 | <0.25 | 0.5 | 0.25 | 1 |
a
CTX, cefotaxime; CAZ, ceftazidime; FEP, cefepime; TZP, piperacillin-tazobactam; DOR, doripenem; IPM, imipenem; MEM, meropenem; CIP, ciprofloxacin; LVX, levofloxacin; GEN, gentamicin; AMK, amikacin; SXT, trimethoprim-sulfamethoxazole; MIN, minocycline; TGC, tigecycline; CST, colistin; and PMB, polymyxin B.
b
Doripenem breakpoint value obtained from Doribax package insert.
c
No breakpoints available for Acinetobacter species.
d
A. calcoaceticus-baumannii complex strain W2AC8-S10 is a KPC-negative, OXA-51-positive susceptible isolate.