FIG. 7.

Virus titers in the lungs of the infected mice treated with the repeated oral administration of oseltamivir phosphate or a single intranasal administration of CS-8958. Virus titers (log₁₀ PFU/lungs) in the mouse lungs after saline administration (closed circles), the repeated administration of oseltamivir phosphate at 1 mg/kg (open triangles) or 10 mg/kg (closed triangles), and a single administration of CS-8958 at 0.057 μmol/kg (open squares) or 0.17 μmol/kg (closed squares) are shown. The virus titers were measured at 35, 59, and 83 h after infection with A/PR/8/34 (30 PFU) at 0 h. For the repeated administrations, oral administration of oseltamivir phosphate and then the intranasal administration of saline were performed at 11 hpi, followed by the oral administration of saline twice daily. For the single administration, CS-8958 was intranasally administered at 11 hpi and saline was orally administered on the same schedule indicated above. For the controls, saline was administered by both routes at 11 hpi and was orally administered at the rest of the time points. The CS-8958 dose of 0.17 μmol/kg corresponds to 0.080 mg/kg. Each plot represents the mean ± standard deviation (n = 3).