TABLE 5.
Minimal set of mutations that can be used to detect MDR strains of Mycobacterium tuberculosisa
| Mutation site | % Sensitivity (% CI) for resistance detection |
||
|---|---|---|---|
| RIF | INH | MDR | |
| rpoB531, rpoB526, rpoB516, rpoB533, or rpoB513 | 93.8 (90.0-96.5) | 82.6 (77.3-87.2) | |
| katG315, inhA-15, or ahpC-10, ahpC-6, or ahpC-12 | 85.5 (80.5-89.7) | ||
| embB306 | 93.8 (90.0-96.5) | 89.3 (84.7-92.9) | 86.8 (81.8-90.8) |
a
A screening test that uses mutations in rpoB531, rpoB526, rpoB516, rpoB533, and rpoB513, katG315, inhA-15, ahpC-10, ahpC-6, and ahpC-12, and embB306 can detect 86.8%(81.8% to 90.8%) of MDR strains(tested using 242 isolates).