. 2010 Jan 11;54(3):1140–1145. doi: 10.1128/AAC.00915-09

TABLE 2.

PBP mutations in laboratory-evolved S. uberis strains

Isolate	No. of cycles	MIC (μg/ml)	Mutations
Isolate	No. of cycles	MIC (μg/ml)	PBP1A	PBP2B	PBP2X
ATCC 19436	0	0.032	—^a	—	—
ATCC 19436	15	0.5	A₂₂₇T	N₃₆₆I/T₄₀₂I	E₃₈₁K/Q₅₅₄E
ATCC 19436	18	1	A₂₂₇T	N₃₆₆I/T₄₀₂I	E₃₈₁K/D₅₂₄A/Q₅₅₄E
ATCC 19436	30	2	A₂₂₇T/G₃₈₆R	N₃₆₆I/T₄₀₂I	E₃₈₁K/D₅₂₄A/Q₅₅₄E
8749	0	0.016	—	N₃₆₆I/T₄₀₂I/V₅₇₀A/P₅₇₅S	A₄₉₂E
8749	16	0.5	R₂₇₃H	N₃₆₆I/T₄₀₂I	E₃₈₁K/Q₅₅₄E
8749	28	1	A₂₂₇T/G₃₈₆R	N₃₆₆I/T₄₀₂I	E₃₈₁K/D₅₂₄A/Q₅₅₄E
8749	37	2	A₂₂₇T/G₃₈₆R	N₃₆₆I/T₄₀₂I	E₃₈₁K/D₅₂₄A/Q₅₅₄E
9529	0	0.128	—	N₃₆₆I/T₄₀₂I	E₃₈₁K/Q₅₅₄E
9529	11	0.5	R₂₇₃P	N₃₆₆I/T₄₀₂I	E₃₈₁K/Q₅₅₄E
9529	28	1	R₂₇₃P	N₃₆₆I/T₄₀₂I	E₃₈₁K/Q₅₅₄E
9529	39	2	A₂₂₇T/G₃₈₆R	N₃₆₆I/T₄₀₂I	E₃₈₁K/D₅₂₄A/Q₅₅₄E

—, no detected mutation.