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. 2009 Dec 28;54(3):1298–1304. doi: 10.1128/AAC.01222-09

FIG. 1.

FIG. 1.

L-AMB and ABLC exhibit different dose-dependent patterns of drug delivery and clearance of Rhizopus oryzae in experimental invasive pulmonary mucormycosis in neutropenic mice. (Top row) Relationship of the R. orzyae burden in the different treatment groups versus time. Each datum point represents the mean ± standard deviation of the R. orzyae CE DNA isolated from the lungs of 10 mice assayed by real-time quantitative PCR. (Bottom row) The corresponding mean ± standard deviation total lung tissue amphotericin B concentrations determined by high-performance liquid chromatography analysis of lung tissue homogenates. Concentrations were corrected for the weight of the lung tissue and the volume of the homogenate. *, P < 0.05 by the Kruskal-Wallis test with Dunn's multiple-comparison test. Dotted lines display the MIC and the MFC of the R. oryzae test strain determined by Etest and the CLSI M38-A2 method (6).