TABLE 1.

Sensitivities of different HCMV laboratory strains to AIC246 and GCV in fibroblast cells

Assay	HCMV strain	EC50(μM)a		EC90 (μM)a		No. of independent expts
		AIC246	Ganciclovir	AIC246	Ganciclovir
CPE-RAb	Davis	0.0040 ± 0.0010	2.70 ± 0.70	NDd	ND	7
	AD169	0.0050 ± 0.0010	4.30 ± 1.80	ND	ND	13
GFP-RAc	AD169-GFP	0.0038 ± 0.0009	1.73 ± 0.93	0.0051 ± 0.0014	10.7 ± 2.5	18
	RV-HG	0.0049 ± 0.0009	2.33 ± 2.75	0.0071 ± 0.0025	18.3 ± 22.7	5

^aEC₅₀ and EC₉₀ values were determined by the indicated antiviral assay. Nonlinear regression analysis was performed, and the resulting graphs were used to calculate the respective values. Results are expressed as means ± standard deviations.

^bCPE reduction assay.

^cFluorescence reduction assay.

^dND, not determined.