TABLE 2.
Antiviral activity of AIC246 determined for various cell types
| Cell type | Drug | EC50a (μM) | CC50b (μM) | SIc |
|---|---|---|---|---|
| HS27 | AIC246 | 0.0056 ± 0.0004 (4) | 107 (2) | 19,107 |
| Ganciclovir | 0.32 ± 0.11 (6) | >333 (2) | >1,044 | |
| NHDF | AIC246 | 0.0035 ± 0.0010 (6) | 91 (2) | 25,899 |
| Ganciclovir | 1.91 ± 1.30 (6) | >333 (2) | >174 | |
| HELF | AIC246 | 0.0035 ± 0.0013 (5) | 63 (2) | 17,877 |
| Ganciclovir | 2.39 ± 1.03 (5) | >333 (2) | >139 | |
| NHLF | AIC246 | 0.0050 ± 0.0020 (5) | 64 (2) | 12,903 |
| Ganciclovir | 2.07 ± 1.01 (5) | >333 (2) | >161 | |
| MRC5 | AIC246 | 0.0045 ± 0.0004 (3) | 127 (2) | 28,015 |
| Ganciclovir | 1.65 ± 0.56 (3) | >333 (2) | >202 |
a
EC50s determined by the fluorescence reduction assay expressed as mean ± standard deviation. The number of independent experiments is shown in parentheses.
b
CC50 values determined by the alamarBlue viability assay as described in Materials and Methods. Values with a > sign represent the highest concentration tested.
c
Selectivity index (SI) = CC50/EC50.