FIG. 5.

Genotypic profiling of compounds 3 and 4 and reference compounds against HCV NS5B chimeric replicons. The black filled symbols refer to the chimeras representing single clones, and the empty white symbols refer to pools of clones. Circles, replicon NS5B chimeric isolate from clinical sera; squares, ET replicon for subtype 1b (23) and H77 chimera for subtype 1a. Inhibitory activities are reported as median EC₅₀s (μM). The median EC₅₀s of each inhibitor for genotypes 1a and 1b are listed in Table 3.