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Estimation of the time of interspecies transmission of SARSr-CoV. Squares denote the MRCA of all SARSr-CoV (1972), the MRCA of human/civet SARSr-CoV and the closest SARSr-Rh-BatCoV (1995), and the MRCA of human and civet SARSr-CoV (2001), respectively.