FIG. 7.

Viral growth kinetics of virulent wild-type and SL3 GNRA viruses in primary bone-derived murine macrophage cells. Sequence-verified stocks of wild-type or SL3 GNRA murine norovirus in the CW1.P1 backbone (see the text for more details) were used to infected either RAW 264.7 cells or primary bone-derived macrophage cells at a multiplicity of infection of 0.01 (based on viral titration in RAW 264.7 cells). Infections were performed in triplicate, and samples were taken at various times postinfection prior to TCID₅₀ titration in RAW 264.7 cells. The average titers were plotted as TCID₅₀/ml, with the standard deviations also shown.