TABLE 1.
Tissue virus loadsa
| Tissue and compartment | VL (copies/106 cells)b |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mmu 35389 (received HAART; plasma VL, 19; CSF VL, <50) |
Mmu 35339 (received HAART; plasma VL, 11; CSF VL, <50) |
Mmu 35343 (received HAART; plasma VL, 28; CSF VL, <50) |
Mmu 35342 (received HAART; plasma VL, 20; CSF VL, <50) |
Mmu 35349 (received HAART; plasma VL, 17; CSF VL, <50) |
Mmu 35483 (no HAART; plasma VL, 128,084; CSF VL, 18,681) |
|||||||
| DNA | RNA | DNA | RNA | DNA | RNA | DNA | RNA | DNA | RNA | DNA | RNA | |
| Lymphoid tissues | ||||||||||||
| Spleen | 290 | 3 | 5 | 3 | 750 | 420 | 370 | 67 | 540 | 33 | 4,200 | 45,000 |
| Mesenteric lymph node | 340 | 8 | 1,100 | 75 | 4,000 | 46 | 520 | 220 | 890 | 98 | 13,000 | 4,800 |
| Axial lymph node | 1,200 | 17 | 77 | 32 | 480 | 360 | 1,600 | 79 | 640 | 710 | 2,300 | 97,000 |
| Inguinal lymph node | 510 | 26 | 89 | 11 | 6,800 | 130 | 110 | 300 | 290 | <1 | 6,100 | 200,000 |
| Iliac lymph node | 440 | 8 | 87 | 46 | 2,400 | 260 | 310 | 6 | 460 | 130 | 10,000 | 67,000 |
| Cervical lymph node | 1,200 | 19 | 510 | 100 | 49 | 340 | 350 | 11 | 320 | 79 | 2,500 | 12,000 |
| Thymus | 45 | 2 | 160 | <1 | 4,800 | 140 | 31 | <1 | 74 | 94 | 140 | 430 |
| Bone marrow | 10 | <1 | <1 | <1 | 340 | <1 | 18 | <1 | <1 | <1 | 17 | 90 |
| Tonsil | 15 | <1 | 720 | 42 | 590 | 670 | 210 | 38 | 430 | 110 | 4,000 | 21,000 |
| GI tract | ||||||||||||
| Duodenum | 230 | 2 | 170 | 46 | 1,000 | 32 | <1 | 5 | 170 | 59 | 5,000 | 150,000 |
| Jejunum | 140 | 8 | 62 | <1 | 200 | 7 | 8 | 8 | 44 | 13 | 330 | 680 |
| Ileum | 88 | 3 | 120 | <1 | 390 | <1 | 140 | 23 | 3,900 | 76 | 93 | 180 |
| Cecum | 3 | <1 | <1 | <1 | 140 | 28 | 64 | 2 | 17 | 150 | 890 | 160 |
| Colon | 70 | <1 | 58 | 8 | 360 | 21 | <1 | <1 | 23 | 190 | 170 | 6,200 |
| Neurological tissues | ||||||||||||
| Cerebrum | <1 | <1 | <1 | <1 | <1 | <1 | 6 | <1 | <1 | <1 | 5 | <1 |
| Cerebellum | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | 3 | <1 | 5 |
| Choroid plexus | 15 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | 5 | <1 | 10 | 13 |
| Cervical spinal cord | 7 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | 4 |
| Lumbar spinal cord | 4 | <1 | 4 | <1 | 220 | <1 | 36 | <1 | <1 | <1 | <1 | 6 |
| Reproductive tissues | ||||||||||||
| Testes | 13 | <1 | 17 | <1 | 10 | <1 | 0 | <1 | 21 | <1 | 88 | 620 |
| Seminal vesicles | 20 | <1 | 0 | <1 | 30 | <1 | 36 | <1 | 4 | <1 | 60 | 150 |
| Prostate | 4 | <1 | 36 | <1 | 180 | <1 | 54 | <1 | 10 | 35 | 160 | 300 |
| Penis | 23 | <1 | <1 | <1 | <1 | <1 | 0 | <1 | <1 | <1 | <1 | 3 |
| Other | ||||||||||||
| Kidney | 3 | <1 | 7 | <1 | <1 | <1 | <1 | <1 | 1 | <1 | 76 | 280 |
| Liver | 6 | <1 | 9 | <1 | <1 | <1 | <1 | <1 | 25 | <1 | 7 | 250 |
| Heart | 9 | <1 | 3 | <1 | 9 | <1 | 17 | <1 | 3 | <1 | 22 | 130 |
| Lung | 3 | <1 | 1 | <1 | 18 | <1 | 14 | <1 | 2 | 9 | 340 | 3,100 |
| Bladder | 6 | <1 | 42 | <1 | <1 | <1 | 11 | <1 | 1 | <1 | 150 | 1,200 |
a
All tissue values are the means for two different tissue samples of each tissue. All values are normalized to 2 × 106 copies of cellular IL-2 DNA measured in each sample.
b
Virus loads in plasma and CSF are given as copies of RT-SHIV RNA per ml of fluid.