Table 2a.

Odds of developing cognitive impairment (unadjusted and multivariate adjusted for age, education and baseline cognition) over 4 years by ESR1 and ESR2 single nucleotide polymorphism genotype in women.

ESR1 SNP Genotype	N With Genotype	% Impaired	Unadjusted OR (95% CI)	Multivariate OR (95% CI)	ESR2 SNP Genotype	N With Genotype	% Impaired	Unadjusted OR (95% CI)	Multivariate OR (95% CI)
rs8179176					rs1255998
GG	151	19	0.61 (0.40-0.94)	0.65 (0.42-1.01)	GG	171	33	1.51 (1.06-2.13)	1.25 (0.87-1.80)
AA or AG	1163	27	1.0 (ref)	1.0 (ref)	CC or CG	1131	25	1.0 (ref)	1.0 (ref)
rs9340799					rs1256065
GG	335	22	0.76 (0.57-1.02)	0.73 (0.54-0.99)	CC	144	16	0.51 (0.32-0.81)	0.56 (0.35-0.88)
AA or AG	965	27	1.0 (ref)	1.0 (ref)	AA or AC	1155	27	1.0 (ref)	1.0 (ref)
rs3728524					rs1256049
GG or GA	255	31	1.33 (0.98-1.80)	1.23 (0.90-1.70)	AA or AG	134	32	1.39 (0.94-2.04)	1.24 (0.83-1.85)
AA	1052	25	1.0 (ref)	1.0 (ref)	GG	1181	25	1.0 (ref)	1.0 (ref)
rs3798577					rs1256030
CC	1007	26	1.04 (0.77-1.39)	1.08 (0.80-1.46)	TT	197	18	0.58 (0.39-0.85)	0.64 (0.43-0.94)
TT or TC	299	26	1.0 (ref)	1.0 (ref)	CC or CT	1108	27	1.0 (ref)	1.0 (ref)

Most common allele frequencies: ESR1 rs8179176 A=58%, rs9340799 A=50%, rs728524 A=88%, rs3798577 T=53%; ESR2 rs1255998 C=70%, rs1256065 A=72%, rs1256049 G=95%, rs1256030 C=64%.