Table 2b.

Odds of developing cognitive impairment (unadjusted and multivariate adjusted for age, education and baseline cognition) over 4 years by ESR1 and ESR2 single nucleotide polymorphism genotype in men.

ESR1 SNP Genotype	N With Genotype	% Impaired	Unadjusted OR (95% CI)	Multivariate adjusted OR (95% CI)	ESR2 SNP Genotype	N With Genotype	% Impaired	Unadjusted OR (95% CI)	Multivariate adjusted OR (95% CI)
rs8179176					rs1255998
GG	115	18	0.74 (0.45-1.21)	0.77 (0.45-1.32)	GG	110	35	1.96 (1.29-3.00)	1.68 (1.06- 2.65)
AA or AG	1034	23	1.0 (ref)	1.0 (ref)	CC or CG	1039	21	1.0 (ref)	1.0 (ref)
rs9340799					rs1256065
GG	245	23	1.03 (0.73-1.44)	1.00 (0.71-1.41)	CC	139	26	1.23 (0.82-1.85)	1.36 (0.88- 2.10)
AA or AG	899	22	1.0 (ref)	1.0 (ref)	AA or AC	997	22	1.0 (ref)	1.0 (ref)
rs3728524					rs1256049
GG or GA	171	32	1.79 (1.25-2.57)	1.54 (1.07-2.23)	AA or AG	122	25	1.21 (0.78-1.86)	1.11 (0.71- 1.75)
AA	977	20	1.0 (ref)	1.0 (ref)	GG	1044	22	1.0 (ref)	1.0 (ref)
rs3798577					rs1256030
CC	249	20	0.87 (0.61-1.23)	0.82 (0.57-1.18)	TT	169	28	1.48 (1.02-2.14)	1.56 (1.07- 2.29)
TT or TC	889	23	1.0 (ref)	1.0 (ref)	CC or CT	971	21	1.0 (ref)	1.0 (ref)

Most common allele frequencies: ESR1 rs8179176 A=67%, rs9340799 A=52%, rs728524 A=91%, rs3798577 T=54%; ESR2 rs1255998 C=74%, rs1256065 A=68%, rs1256049 G=95%, rs1256030 C=62%.