Table 4.
Clavulanic acid | Tazobactam | Sulbactam | |
---|---|---|---|
kcat(s-1) | (2.5 ± 0.1) × 10-2 | (8.9 ± 0.3) × 10-2 | (9.5 ± 0.2) × 10-2 |
kinact(s-1) | (1.2 ± 0.1) × 10-2 | (1.3 ± 0.1) × 10-3 | (4.4 ± 0.2) × 10-4 |
Ki (μ M) | 2.5 ± 0.3 | 1.8 ± 0.3 | 17.0 ± 3.0 |
Partition ratio | 2.1 ± 0.1 | 66 ± 2 | 218 ± 4 |
Partition ratio (TEM-1)25 | 125 ± 36 | 475 ± 42 | 10,000 |