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. Author manuscript; available in PMC: 2011 Jan 20.
Published in final edited form as: J Am Chem Soc. 2010 Jan 20;132(2):816–823. doi: 10.1021/ja908850p

Table 4.

Inhibition profile of the OIH-1 β-lactamase for β-lactamase inhibitors

Clavulanic acid Tazobactam Sulbactam
kcat(s-1) (2.5 ± 0.1) × 10-2 (8.9 ± 0.3) × 10-2 (9.5 ± 0.2) × 10-2
kinact(s-1) (1.2 ± 0.1) × 10-2 (1.3 ± 0.1) × 10-3 (4.4 ± 0.2) × 10-4
Ki (μ M) 2.5 ± 0.3 1.8 ± 0.3 17.0 ± 3.0
Partition ratio 2.1 ± 0.1 66 ± 2 218 ± 4
Partition ratio (TEM-1)25 125 ± 36 475 ± 42 10,000