Table 4.

Prospective analyses (risk of incident disease with antihypertensive medication use)

Antihypertensive agent	Essential tremor	Parkinson's disease	Dementia
Any antihypertensive agent	1.46 (0.95–2.26), 0.09	0.90 (0.44–1.85), 0.77	1.21 (0.89–1.64), 0.24
	1.46 (0.92–2.31), 0.11	1.11 (0.51–2.39), 0.80	0.98 (0.71–1.36), 0.91
Any antihypertensive agent (excluding β-blockers)	1.41 (0.91–2.16), 0.12	0.96 (0.47–1.97), 0.91	1.25 (0.90–1.71), 0.15
	1.59 (0.98–2.57), 0.06	1.17 (0.54–2.53), 0.69	0.99 (0.71–1.38), 0.96
Calcium channel blockers	1.60 (0.90–2.84), 0.11	1.24 (0.43–3.55), 0.69	1.26 (0.80–1.97), 0.32
	1.62 (0.91–2.90), 0.10	1.24 (0.43–3.60), 0.69	1.02 (0.64–1.62), 0.95

In Cox proportional hazards models, diagnosis (essential tremor vs. control, Parkinson's disease vs. control, dementia vs. control, in different models) was the outcome variable and use of an antihypertensive agent was the predictor variable. Unadjusted models are reported (upper row in each cell) and then models that adjusted for age, gender, education, and depressive symptoms (lower row in each cell). Results are given as the risk ratio (95% CI) and p values.