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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Cell Signal. 2010 Jan 11;22(5):749–758. doi: 10.1016/j.cellsig.2009.12.010

Figure 1.

Figure 1

Simvastatin inhibits phosphorylation of Akt. (A) Effect of simvastatin on phosphorylation of Akt in MDA-MB-231 breast cancer cells. Lysates of cells incubated with 10 μM simvastatin (SIM) for 24 hours were immunoblotted with phospho-Akt (Ser-473) and Akt antibodies respectively (B) Simvastatin prevents phosphorylation of Akt in the MDA-MB-231 xenografts. Lysates of tumors from independent control and independent simvastatin-treated mice were immunoblotted with phospho-Akt and actin antibodies as indicated. (C) Quantification of phosphorylated Akt in the panel B. Mean ± SE of three independent animals is shown. *p < 0.01 vs, control.