Figure 3.
E. coli infection on P4 increases microgliogenesis and decreases proliferation of non-microglial cells in the hippocampus. Rats received injections of either E. coli or PBS vehicle on P4 and BrdU on P4 and P5 and were killed on P6. E. coli infection produced increases in total microglia, activated microglia, and proliferating microglia (BrdU + Iba1) and decreases in proliferating non-microglial cells (BrdU only) in CA1 (A) and CA2 (B) but not DG (C). Values are means ± SEMs of 9 to 11 rats/group. * Significantly different from PBS, p < .05. ** Significantly different from PBS, p < .01.