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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Respir Med. 2009 Oct 31;104(3):454–462. doi: 10.1016/j.rmed.2009.10.004

Figure 1. Circulating blood CD8+ T lymphocyte subsets are abnormal in IPAH.

Figure 1

Circulating blood lymphocytes were analyzed by flow cytometry in IPAH and control subjects. Patients with IPAH have a significantly higher percentage of CD45RA+CCR7- CD8+ T lymphocytes (left box) and a significantly lower percentage of CD45RA+CCR7+ CD8+ T lymphocytes. (A) Box plots demonstrate the median value (line), and inter-quartile range for each group (grey boxplots are IPAH group and open boxplots are Control group; note that values in the text are given as mean ± S.D.). (B) Representative flow cytometric dot plots from an IPAH patient (left panel) and a healthy control (right panel). CD8+ T cells were gated based on CCR7 and CD45RA expression. The numbers in the corners indicate the percentages of cells within that particular quadrant.