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Anti-HBV activity of the prodrug 3 against wild-type and drug-resistant HBV mutants.
| Virus | Strain | EC50 of 3 (μM) |
EC90 of 3 (μM) |
Control: 3TC (μM) | Control: ADV (μM) | ||
|---|---|---|---|---|---|---|---|
| EC50 | EC90 | EC50 | EC90 | ||||
| HBV | WT | 2.5 | 8.5 | 0.2 | 0.7 | 1.5 | 7 |
| HBV-3TC-R1 | L180M | 2.1 | 8.6 | 5.3 | 20 | 2.1 | 8.2 |
| HBV-3TC-R2 | M204V | 2.4 | 8.3 | >100 | >100 | 1.8 | 7.2 |
| HBV-3TC-R3 | M204I | 3 | 9.2 | >100 | >100 | 2 | 8 |
| HBV-3TC-R4 | LMMV | 3.1 | 9.3 | >100 | >100 | 2.2 | 8.3 |
| HBV-ADV-R1 | N236T | 2.8 | 8.7 | 0.2 | 0.8 | 7.5 | 29 |
