Figure 4.

Role of Gly-Ala repeat (GAr) on the presentation of the LQT epitope. LQT-specific cytotoxic T-lymphocyte (CTL) clones were tested against untreated or LQT-pulsed BJAB cells or BJAB cells stably expressing Epstein–Barr virus nuclear antigen 1 (EBNA1; E1) (central chart) or the GAr-deleted form (E1ΔGA) (lower chart). Results are expressed as the per cent specific lysis obtained at an effector : target ratio of 3 : 1. One representative experiment out of three is shown. In the upper panel, expression of EBNA1 (E1) and GAr-deleted EBNA1 (E1ΔGA) in transfected BJAB cells, as detected by Western blot analysis, is shown.