Table 4.

Multivariate Cox regression analysis of the prognostic significance of the risk group determined by the gene expression classifier for RFS in the presence of genetic factors in ALL associated with a poor outcome

Covariates	Hazard ratio*		P
	Estimate	95% confidence interval
Gene expression classifier for RFS risk group
High risk versus low risk	2.380	2.3.6-4.338	.005
IKAROS/IKZF1 deletions
Positive versus negative	2.237	1.316-3.803	.003
JAK mutations
Positive versus negative	1.020	.500-2.081	.957
Kinase gene expression signature
Positive versus negative	1.094	.590-2.030	.774

The gene expression classifier for RFS used in this analysis is the initial classifier developed with 42 probe sets (38 unique genes) provided in supplemental Table 4.

^*Hazard ratios and corresponding P value are based on Cox regression.