. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Curr Opin Pharmacol. 2009 Oct 12;9(6):680–687. doi: 10.1016/j.coph.2009.09.006

Table 3.

PRR polymorphisms associated with Gastrointestinal Cancer

Polymorphisms/Mutations	Cancer
TLR2 (−196 to −174del/del)	Non-cardiac gastric cancer in Japanese population [85]
TLR4 (Thr135Ala)	Poorly differentiated gastric adenocarcinomas [86] Gastric cancer [87]
(Asp299Gly)	Gastric cancer [87]
(Thr399Ile)	Pre-malignant lesions [88]
NOD2 (3020insC)	Colorectal cancer in older Polish patients [89]
NOD2 (R702W, G908R, 3020insC)	Colorectal cancer in Greek population [90] Not associated with gastric cancer in Caucasian population [91] Not associated with colorectal cancer in Hungarian subjects [92]
TLR2 (microsatellite GT)	Colorectal cancer in Croatian patients [93]
TLR4 (Asp299Gly)