Figure 6.

Nt5e^−/− mice show enhanced nociceptive responses following inflammation and nerve injury. A, B, CFA inflammatory pain model. WT and Nt5e^−/− mice were tested for (A) thermal and (B) mechanical sensitivity before (BL) and following injection of CFA (arrow) into one hindpaw. The contralateral hindpaw served as control. C, D, SNI neuropathic pain model. WT and Nt5e^−/− were tested for (C) thermal and (D) mechanical sensitivity before (BL) and after ligation and transaction of the sural and common peroneal branches of the sciatic nerve. A–D, Paired t tests were used to compare responses at each time point between WT and Nt5e^−/− mice (n = 10 per genotype); same paw comparisons. *p < 0.05, **p < 0.005, ***p < 0.0005. All data are presented as means ± SEM.