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TUNEL staining of tumors collected on day 3 of treatment shows increased apoptosis (arrow indicates an apoptotic cell) in tumors treated with Apo2L/TRAIL in combination with CPT-11 over either treatment alone. a–d Tumor 11124. a Control = 1.8%. b Apo2L/TRAIL = 10.9%. c CPT-11 = 3.2%. d Apo2L/TRAIL + CPT-11 = 18.3%. e–h Tumor 11501. e Control = 2.3%. f Apo2L/TRAIL = 3.0%. g CPT-11 = 5.0%. h Apo2L/TRAIL + CPT-11 = 9.7%.
