Table 1.
Shift in the frequency of the asymmetric α-carboxylate vibration for the agonist bound to the GluR2-S1S2 wild type, L650T, and Y450F proteins relative to the frequency in buffer and of the Cys 425 S-H stretching vibration in the agonist-bound state relative to the frequency of the vibration in the apo state (37). Reproduced with permission from Biochemistry 2007; 46: 1343–1349. Copyright 2007 American Chemical Society.
| Protein-Agonist | α-carboxylate shift (cm−1) |
SH shift (cm−1) |
|---|---|---|
| WT-AMPA | 9 | 18 |
| Y450F-AMPA | 9 | 20 |
| L650T-AMPA | 10 | 0 |
| WT-Glutamate | 4 | 18 |
| Y450F-Glutamate | 5 | 0 |
| L650T-Glutamate | 4 | 20 |
| WT-Kainate | 18 | 0 |
| Y450F-Kainate | 14 | 11 |
| L650T-Kainate | 13 | 16 |