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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Exp Gerontol. 2010 Jan 11;45(3):217–234. doi: 10.1016/j.exger.2010.01.004

Figure 1. FoxO3a can control the activity of caspase 3.

Figure 1

Inflammatory microglial cells were exposed to oxidative stress through oxygen-glucose deprivation (OGD) and caspase 3 activation was determined six hours after OGD exposure through immunocytochemistry with antibodies against cleaved active caspase 3 (17 kDa). Representative images show no caspase 3 activity staining (blue) in control (untreated cells), but active caspase 3 staining (red) in cells following OGD. In contrast, gene silencing of FoxO3a during transfection with FoxO3a siRNA yields significantly reduced caspase 3 activity with demonstration of minimal red staining.