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Phosphorylation of MAP Kinases increases with age in heart tissues from WT and Sod2+/− mice. Phosphorylation of different members of the MAP Kinase pathway Erk (A), JNK (B) and p38 (C) was determined by Western blotting. Values reported as relative densitometric intensity and represented as mean ± SE. n = 4 for each group in p-Erk. n = 4 for young and old WT and n = 5 for young and old Sod2+/− in p-JNK, n = 2 for all groups in p-p38.
