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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Immunol. 2009 Sep 14;183(7):4569–4582. doi: 10.4049/jimmunol.0901734

Figure 2. Mutation at position 283 in D2 uniquely changes the capacity of KIR3DL1*015 to bind anti-KIR3DL1 monoclonal antibodies.

Figure 2

Panel A shows the proportion of mutations that affect antibody binding and their distribution between the various domains of KIR3DL1*015. Panel B summarizes the effects of mutation on the binding of antibodies DX9, Z27 and 177407, and shows that only mutation at position 283 both increase (177407) or decrease (DX9 and Z27) the binding of different antibodies. Reduction and increase of antibody binding are indicated by downward and upward pointing arrows respectively. Absence of an arrow denotes no effect on antibody binding.