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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Immunol. 2009 Sep 14;183(7):4569–4582. doi: 10.4049/jimmunol.0901734

Figure 9. Binding of A24nef to mutants of 3DL1*015 and 3DL1*005.

Figure 9

Mutant KIR3DL1 were transfected into Jurkat cells and tested for binding A*24nef as described in the legend to figure 5. From the structural model all the mutations were predicted to perturb the interaction between 3DL1 and A24nef. The substitutions at positions 163, 166 and 199 abrogate A24nef binding, but not the binding of anti-3DL1 antibodies (Figure 3B) are all ones present in KIR3DS1.