Table 2. Regional mapping for FSGS associations with MYH9 and four nearby genes.
| SNP association (local ancestry correction) |
|||||
|---|---|---|---|---|---|
| Uncorrected |
Correcteda |
||||
| SNPb | Genomic position (Mb) | OR (95% CI)c | Pd | OR (95% CI) | P |
|
RBM9
| |||||
| rs5750175 | 34.479 | 0.89 (0.67,1.17) | 0.40 | 0.60 (0.44,0.83) | 0.002 |
| rs5755943 | 34.496 | 1.08 (0.81,1.44) | 0.59 | 0.84 (0.62,1.15) | 0.28 |
|
| |||||
|
MYH9
| |||||
| rs7078 | 35.008 | 2.03 (1.29,3.20) | 0.002 | 1.49 (0.91,2.44) | 0.11 |
| rs12107 | 35.008 | 2.51 (1.35,4.64) | 0.003 | 1.81 (0.93,3.52) | 0.08 |
| rs735853 | 35.009 | 10.75 (3.82,30.3) | 7 × 10−6 | 5.65 (1.89,16.92) | 0.002 |
| rs5756129 | 35.014 | 2.74 (1.74,4.30) | 1 × 10−5 | 2.38 (1.49,3.81) | 0.0003 |
| rs5756130 | 35.014 | 0.49 (0.29,0.82) | 0.007 | 0.43 (0.25,0.74) | 0.002 |
| rs11549907 | 35.015 | 0.55 (0.30,0.98) | 0.04 | 0.49 (0.27,0.89) | 0.02 |
| rs875725 | 35.022 | 0.46 (0.26,0.81) | 0.008 | 0.40 (0.22,0.73) | 0.002 |
| rs2187776 | 35.025 | 1.21 (0.89,1.65) | 0.23 | 1.09 (0.79,1.50) | 0.61 |
| rs4821480 | 35.025 | 4.18 (2.74,6.40) | 4 × 10−11 | 2.96 (1.78,4.94) | 3 × 10−5 |
| rs2032487 | 35.025 | 3.95 (2.66,5.86) | 9 × 10−12 | 2.91 (1.85,4.58) | 4 × 10−6 |
| rs4821481 | 35.026 | 4.13 (2.78,6.12) | 2 × 10−12 | 2.95 (1.81,4.81) | 1 × 10−5 |
| rs3752462 | 35.040 | 3.88 (2.50,6.02) | 1 × 10−9 | 2.75 (1.72,4.40) | 2 × 10−5 |
| rs5756152 | 35.042 | 2.77 (2.04,3.76) | 7 × 10−11 | 2.34 (1.71,3.21) | 1 × 10−7 |
| rs1557539 | 35.044 | 0.34 (0.13,0.92) | 0.03 | 0.41 (0.14,1.19) | 0.10 |
| rs1005570 | 35.045 | 2.85 (2.07,3.92) | 1 × 10−10 | 2.28 (1.63,3.19) | 1 × 10−6 |
| rs16996674 | 35.057 | 2.14 (1.58,2.90) | 9 × 10−7 | 1.76 (1.29,2.42) | 0.0004 |
| rs16996677 | 35.057 | 2.28 (1.69,3.06) | 6 × 10−8 | 1.86 (1.37,2.54) | 8 × 10−5 |
|
| |||||
|
PVALB
| |||||
| rs736721 | 35.533 | 1.58 (1.17,2.14) | 0.003 | 1.49 (1.10,2.04) | 0.01 |
| rs739031 | 35.538 | 1.57 (1.14,2.16) | 0.006 | 1.25 (0.89,1.75) | 0.19 |
| rs2269511 | 35.541 | 1.09 (0.83,1.44) | 0.53 | 0.89 (0.66,1.2) | 0.44 |
|
| |||||
|
TST
| |||||
| rs5756477 | 35.737 | 1.10 (0.82,1.47) | 0.53 | 1.03 (0.76,1.40) | 0.84 |
| rs130598 | 35.738 | 1.28 (0.92,1.79) | 0.14 | 0.97 (0.68,1.40) | 0.88 |
| rs470029 | 35.740 | 1.58 (1.11,2.26) | 0.01 | 1.42 (0.99,2.04) | 0.06 |
|
| |||||
|
TMPRSS6
| |||||
| rs855788 | 35.804 | 2.62 (1.69,4.05) | 2 × 10−5 | 1.65 (0.99,2.74) | 0.05 |
| rs855787 | 35.805 | 1.15 (0.83,1.60) | 0.39 | 1.01 (0.72,1.42) | 0.94 |
| rs2543519 | 35.810 | 1.39 (1.03,1.86) | 0.03 | 1.36 (1.00,1.85) | 0.05 |
| rs1421312 | 35.818 | 1.11 (0.84,1.47) | 0.44 | 0.99 (0.74,1.32) | 0.92 |
a
SNP association with the estimated local chromosomal ancestry, determined by including that SNP in ANCESTRYMAP, included as a covariate in the logistic regression.
b
Genomic positions refer to NCBI build 36.
c
Odds ratio and P from logistic regression under the log additive model, limited to the African American FSGS cases (n = 190) and controls (n = 222) included in the MALD scan.
d
P values in boldface are less than the Bonferroni correction cutoff of 0.0005.