Table 2.

The strengths and challenges for each Social Entrepreneurship Approach (SEA) Element and the corresponding milestones achieved

SEA Element	Strengths	Challenges	Milestones
Element #1	• Able to ensure research addresses a priority topic • Partnership building at initial stages of research	• Time to initiate project • Ensuring that all voices are given equal weight	• Ethical approvals achieved • Research collaboratively implemented
Element #2	• Approach the health issue from multiple perspectives • Mitigates inherent power differences between partners	• Organization of a large international team • Time commitment to create and sustain equitable partnerships	• Strong partnership with BUCHS and local hospital • Multi-disciplinary training delivered to local and international partners
Element #3	• Flexibility allows the project to remain relevant • Initial feasibility assessment enhances likelihood of success	• Adaptations increase time to complete research • Ensure that the adaptation does not introduce bias	• Increased communication between physicians and laboratory • Recruitment of experienced laboratory technician
Element #4	• Emphasis on societal impact allows for alternate funding sources • Local ownership leads to stakeholder motivation and retention	• Funding streams are discipline and disease specific • Under-resourced and over-committed local institutions	• In-kind donations of materials and local and international staff time • Capacity built to support local ownership of research
Element #5	• High level of knowledge translation • Promotion of long term sustainability	• Difficulty mobilizing resources at the national level • Local constraints of time and money	• Trained all interested local staff in multi-disciplinary topics • Strengthening of south-south partnerships