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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Immunol. 2008 Jan 15;180(2):1207–1216. doi: 10.4049/jimmunol.180.2.1207

FIGURE 6.

FIGURE 6

Effect of inhibitors of signal transduction on IL-18 induction following H. pylori infection. Human cells were incubated with SB203580, U0126, or MG-132 for 1 h and subsequently cocultured with wild-type H, pylori strains at an MOI of 100 for 20 h (A) or 3 h (B). IL-18 protein levels released from human cells were determined by ELISA (A) and IL-18 mRNA expression levels by absolute quantitative real-time RT-PCR normalized to GAPDH mRNA. At least three independent cocultures were performed and each was measured in triplicate. Data are expressed as mean ± SE. *, p < 0.01 and **, p < 0.001 compared with wild-type H. pylori infected controls without inhibitors by nonpaired t test.