Table 2.
Phenotypic and genotypic characteristics of methicillin-resistant Staphylococcus aureus strains used to induce persistent bacteremia (PB) or resolving bacteremia (RB) in an infective endocarditis model.
| Characteristic | PB strain 420 | RB strain 1507 |
|---|---|---|
| Phenotypica | ||
| tPMP-1 susceptibilityb | 61 ± 11 | 9 ± 3.5 |
| Fibrinogen binding | 15.2 ± 2.3 | 7.4 ± 1.6 |
| Fibronectin binding | 17.0 ± 0.2 | 1.3 ± 0.1 |
| Platelet binding | 16.6 ± 3.7 | 17.7 ± 2.2 |
| Endothelial cell binding | 12.7 ± 0.4 | 7.3 ± 0.2 |
| Membrane fluidity, polarization index ± SD | 0.319 ± 0.005 | 0.333 ± 0.016 |
| Genotypic | ||
| MLST | CC30 | CC8 |
| spa type | 16 | 7 |
| SCCmec type | II | IV |
| agr type | III | I |
| pvl | Absent | Absent |
| cna | Present | Absent |
| cap type | 8 | 5 |
| tst | Present | Absent |
NOTE. MLST, multilocus sequence type; SCCmec, staphylococcal cassette chromosome mec.
a
Data are percentage of isolates (±SD), unless otherwise indicated.
b
Data are percentage of isolates that survived exposure to 1 μg/mL of tPMP-1.