Table 3.
Phenotypic and genotypic characteristics of methicillin-resistant Staphylococcus aureus strains used to induce persistent bacteremia (PB) or resolving bacteremia (RB).
| Characteristic | PB isolates (n = 21) |
RB isolates (n = 18) |
P |
|---|---|---|---|
| Phenotype | |||
| hNP-1 susceptibilitya | 52 ± 5 | 36 ± 10 | <.05 |
| Fibrinogen bindingb | 21 ± 4 | 14 ± 6 | <.05 |
| Membrane fluidity, polarization index | 0.276 (more fluid) | 0.290 (less fluid) | .11 |
| Genotype | |||
| MLST CC30 | 19 (90) | 8 (44) | <.05 |
| spa16 | 12 (57) | 7 (39) | .16 |
| SCCmec type II | 20 (95) | 13 (72) | <.05 |
| agr type III | 17 (81) | 8 (44) | <.05 |
| cna | 18 (85) | 10 (56) | .07 |
| cap5 | 3 (14) | 11 (61) | <.05 |
| cap8 | 18 (86) | 7 (39) | <.05 |
| pvl | 0 (0) | 0 (0) | NS |
| tst | 18 (86) | 8 (44) | <.05 |
NOTE. Data are no. (%) of isolates, unless otherwise indicated. The following genes were also tested, but there were no significant differences between PB and RB isolates: bsaA1, sea-e, sej, sem, sei, seg, seo, sen, sdrC-E, bbp, ebpS, icaA, efb, sbl, ssp, clfB, splB, fnbA, lukDE, lukM, and EDIN. CC30, clonal complex 30; MLST, multilocus sequence type; NS, not signficant; SCCmec, staphylococcal cassette chromosome mec.
a
Data are percentage of isolates (±SD) that survived exposure to 40 μg/mL of hNP-1.
b
Data are percentage of isolates (±SD) that bound to fibrinogen.