Table 4.

Densities of Staphylococcus aureus strains that induced persistent bacteremia (PB) or resolving bacteremia (RB) in target tissues of an infective endocarditis model, with or without vancomycin therapy.

Group, isolate type	Animals, no.	Inoculum, cfu	Received 15 mg/kg vancomycin	MRSA density, log10 cfu/g of specimen, mean ± SD
				Vegetations	Kidneys	Spleen
Group 1
PB	7	104	No	7.21 ± 0.72	5.31 ± 0.11	4.76 ± 0.51
RB	6	104	No	6.28 ± 1.18	5.41 ± 1.83	4.88 ± 1.68
Group 2
PB	9	105	No	7.46 ± 1.53	5.23 ± 0.91	4.83 ± 1.54
RB	9	105	No	7.61 ± 1.34	5.53 ± 0.73	5.12 ± 0.50
Group 3
PB	8	105	Yes	4.23 ± 1.41a	2.19 ± 0.23a	2.38 ± 0.50a
RB	7	105	Yes	2.31 ± 0.92b	1.81 ± 0.63c	1.96 ± 0.38c

NOTE. The PB isolate was strain 420, and the RB isolate was strain 1507.

^aP < .005, compared with the density in corresponding specimens from PB controls from group 2.

^bP < .01, compared with the density in corresponding specimens from RB controls from group 2.

^cP < .005, compared with the density in corresponding specimens from RB controls in group 2.