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. 2010 Feb 24;5(2):e9386. doi: 10.1371/journal.pone.0009386

Figure 13. Apoptosis regulatory proteins content in the quadriceps of CR vs. AL G93A mice.

Figure 13

(A) Bax was significantly higher in CR vs. AL mice (41%, P = 0.027; main effect of diet). Bax was increased in CR vs. AL females (52%, P = 0.048). (B) There was no significant difference in Bcl-2 protein content. (C) Bax/Bcl-2 was significantly higher in CR vs. AL mice (68%, P = 0.040; main effect of diet). Bax/Bcl-2 was increased in CR vs. AL females (2.3-fold, P = 0.029). No significant changes were observed in the protein content of: (D) caspase 9, (E) cleaved caspase 9, and (F) the ratio of cleaved caspase 9/caspase 9 for diet or sex. Data are presented as means ± SEM. n = 27; AL, 7 males and 7 females; CR, 7 males and 6 females. Asterisks denote significant changes (P≤0.05 vs. AL).