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. 2010 Feb 24;5(2):e9393. doi: 10.1371/journal.pone.0009393

Figure 2. Performance characteristics of pentaplex markers based on QMVR, availability of normal DNA, and numbers of markers required to determine MSI in colorectal cancers.

Figure 2

A) The figure illustrates the performance of the pentaplex mononucleotide-repeat maker panel when defining the MSI status of tumor DNA by “QMVR only” (when matched normal DNA was not available) and by “Normal DNA” by subtracting the germline allele lengths from tumor for each tumor. Data in the two panels on the left is from MMR-deficient tumors, while the other two panels on the right represent MMR-proficient CRCs. (* indicates one case with loss of both MLH1 and MSH2). Black squares indicate a tumor positive for allelic variation (i.e., unstable) and white squares indicate a tumor negative for any allele variations (i.e., stable). B) Shows the frequency of MMR-deficient tumors with number of markers displaying allelic variations when data were analyzed from all five pentaplex markers. C) Shows the frequency of MMR-deficient tumors with number of markers displaying allelic variations when data were analyzed from just three pentaplex markers (BAT26, NR21 and NR27).