Table 2. Performance characteristics of each MSI Marker by different strategies for the identification of MMR-Deficient CRCs.

Marker	Reference	Sensitivity % (95%CI)	Specificity % (95%CI)	PPV % (95%CI)#	NPV % (95%CI)+
BAT25	QMVR	90.4 (83.5–94.5)	96.0 (90.1–98.4)	96.2 (90.8–98.5)	89.6 (82.4–94.1)
	Normal DNA	86.0 (78.4–91.2)	97.0 (91.5–99.0)	97.0 (91.6–99.0)	85.7 (78.0–91.0)
BAT26	QMVR	94.7 (89.0–97.6)	97.0 (91.5–99.0)	97.3 (92.4–99.1)	94.1 (87.8–97.3)
	Normal DNA	95.6 (90.1–98.1)	97.0 (91.5–99.0)	97.3 (92.4–99.1)	95.1 (88.9–97.9)
NR21	QMVR	87.7 (80.4–92.5)	100 (96.3–100)	100 (96.3–100)	87.6 (80.3–92.5)
	Normal DNA	89.5 (82.5–93.9)	100 (96.3–100)	100 (96.4–100)	89.2 (82.0–93.7)
NR24	QMVR	86.8 (79.4–91.9)	99.0 (94.5–99.8)	99.0 (94.6–99.8)	86.7 (79.2–91.8)
	Normal DNA	85.1 (77.4–90.5)	95.0 (88.7–97.8)	95.1 (89.0–97.9)	84.7 (76.8–90.2)
NR27	QMVR	93.9 (87.9–97.0)	99.0 (94.5–99.8)	99.1 (94.9–99.8)	93.3 (86.9–96.7)
	Normal DNA	94.7 (98.0–97.6)	96.0 (90.1–98.4)	96.4 (91.2–98.6)	94.1 (87.6–97.2)

^#PPV  =  positive predictive value.

⁺NPV  =  negative predictive value.