Table 3. Performance characteristics of Pentaplex PCR system with reference to “QMVR” for Identification of MMR-deficient CRCs.

No. of Markers Displaying Allelic Variation	The Five Marker Panel*				The Three Marker Panel**
	Sensitivity (%)	Specificity (%)	PPV (%)#	NPV (%)+	Sensitivity (%)	Specificity (%)	PPV (%)#	NPV (%)+
5	78.9 (70.6–85.4)	100 (96.3–100)	100 (95.9–100)	80.5 (72.6–86.5)
4	87.7 (80.4–92.5)	100 (96.3–100)	100 (96.3–100)	87.6 (80.3–92.5)
3	93.9 (87.9–97.0)	100 (96.3–100)	100 (96.5–100)	93.4 (87.0–96.8)	85.1 (77.4–90.5)	100 (96.3–100)	100 (96.2–100)	85.3 (77.8–90.6)
2	95.6 (90.1–98.1)	100 (96.3–100)	100 (96.6–100)	95.2 (89.2–97.9)	93.9 (87.9–97.0)	100 (96.3–100)	100 (96.5–100)	93.4 (87.0–96.8)
1	97.4 (92.5–99.1)	90.9 (83.6–95.1)	92.5 (86.4–96.0)	96.8 (90.9–98.9)	97.4 (92.5–99.1)	96.0 (90.1–98.4)	96.5 (91.4–98.6)	96.9 (91.4–99.0)

Results are expressed as percentages (%), with 95% confidence intervals in parentheses.

*The Five Pentaplex Marker Panel composed of BAT25, BAT26, NR21, NR24 and NR27 markers.

**The Three Pentaplex Marker Panel composed of BAT26, NR21 and NR27 markers.

^#PPV  =  positive predictive value.

⁺NPV  =  negative predictive value.