Multivariable-adjusted log hazards (solid lines) and 95% CI (dashed lines) of all-cause mortality and the composite outcome of predialysis mortality or ESRD associated with time-varying levels of serum calcium concentration in Cox models adjusted for time-varying age, race, CCI, diabetes mellitus, CVD, BP, body mass index, smoking status, the use of phosphate binders and calcitriol, enrollment period, estimated GFR, bicarbonate, phosphorus, ALP, blood hemoglobin, WBC count, percentage of lymphocytes, and 24-hour urine protein. Superimposed is a histogram showing the distribution of time-varying serum calcium levels.