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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Comp Neurol. 2006 Mar 1;495(1):133–148. doi: 10.1002/cne.20871

Figure 1. Time course of the emergence of hippocampal heterotopia in the MAM-exposed brain.

Figure 1

A–B: Comparison of normal (A) and MAM-exposed (B) rat brains at P0. At this age, nodules in the cortical neuroepithelium (arrow in B) protruded into the ventricle. The cortical plate was also obviously disrupted (arrowhead in B); these abnormalities were not present in control brain sections. C and C′: MAM-exposed rat hippocampal section at P1. The arrow indicates a nodule bridging the neocortical-hippocampal junction. D: At P2, heterotopia (arrow) reached the hippocampus proper, physically integrating into the CA subfields. E: A section at P22 showing the disruption of the CA1 field by heterotopic neocortical neurons (arrow). Scale bars: A,C,E = 200mm; B,D = 500mm; C′ = 100mm