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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Comp Neurol. 2006 Mar 1;495(1):133–148. doi: 10.1002/cne.20871

Figure 2. Histologic analysis of neocortical changes in MAM-exposed rats.

Figure 2

A and B: Coronal brain sections of normal (A) and MAM-exposed (B) animals at gestational day 17 (E17). A′ and B′: Higher magnification pictures of normal (A′) and MAM (B′) neocortex demonstrated early evidence of disruption of the cortical plate with the appearance of gaps (arrow in B′). C and D: At E19, the differences between normal (C) and MAM (D) brains were more apparent. The entire neocortex and hippocampus were smaller in the MAM brain. C′ and D′: Higher magnification images of the neocortex of normal (C′) and MAM (D′) brains showed that the cortical plate was dramatically thinner and indistinct. In general the laminar architecture of the normal neocortex (labels in C′) was obliterated, also the VZ and SVZ showed collections of cells (arrowhead in D′) alternating with cell poor areas indicated severe disorganization of the structural integrity of these layers. E: Quantification of cortical thickness shows that the normal neocortex was almost twice as wide as that of an MAM-exposed brain; normal thickness averaged 596 ±17.2mm while in the MAM brain, the average was 332 ± 8.6mm; n=5 per group. CP = cortical plate; IZ = intermediate zone; SVZ = subventricular zone; VZ = ventricular zone; Scale bars: A,B = 500mm; C,D = 200mm; A′–D′ = 50mm.