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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Comp Neurol. 2006 Mar 1;495(1):133–148. doi: 10.1002/cne.20871

Figure 3. Heterotopia formation is associated with disorganization of cell-cell contacts.

Figure 3

A–B: In P2 control brains there were tightly organized cell-cell contacts at the point of apposition of the neocortical and hippocampal ventricular zones (white dashed line in B). C and D: In a brain from a MAM-exposed rat at P2, a heterotopic cluster of neurons with chaotic β-catenin staining (outlined by the black dashed line in D) had disrupted the formation of the CA1 subfields. E and F: In a case where the heterotopia was still bridging the neocortical and hippocampal ventricular zones (E), the cells away from the nodule maintained their well ordered β-catenin staining (dashed white line in F) but in the region of the nodule it was clear that the normal architecture of this junction was |compromised and β-catenin staining was chaotic (dashed black line in F). Scale bars: low magnification = 250mm; high magnification = 130mm.