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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Comp Neurol. 2006 Mar 1;495(1):133–148. doi: 10.1002/cne.20871

Figure 4. Disintegration of the radial glial scaffold.

Figure 4

A–D: Comparison of nestin expression, a marker for radial glia, at E16, one day after MAM exposure. The control brain (A and C) and the MAM brain (B and D) had similar nestin staining patterns. E–H: By E19, radial glial fibers were severely disrupted in the MAM neocortex (F and H). Instead of the normal radial orientation (G), the radial glial scaffold was tangled (arrowhead in H) with many abnormally thick processes (arrow). I and J: GFAP expression at E19 demonstrated early astrocytic differentiation in the MAM brain (J) when compared to control (I). Scale bars: A,B,E,F,I,J = 200mm; C,D = 100mm; G,H = 50mm.