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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: J Comp Neurol. 2006 Mar 1;495(1):133–148. doi: 10.1002/cne.20871

Figure 8. Reelin-positive cells are Cajal-Retzius cells.

Figure 8

Double immuno-labeling for reelin and calretinin (A, A′, D D′) showed that many of the reelin-positivecells in the MZ of E19 control brains (A, A′) also expressed calretinin (CR). In the MAM brain (C, C′) both the reelin-positive cells in MZ and those in deeper layers co-labeled with calretinin (arrowheads in D′). Calretinin expression also delineated the subplate in the rat (arrowhead in A) and showed that the integrity of this structure was lost in the MAM-treated brain (agreeing with the CSPG data shown above). (B, B′, D. D′) Double in situ hybridization for reelin and p73 expression showed co-labeling of reelin with p73, a very specific marker of C-R cells. Even the chaotically organized reelin-positive cells in deeper layers were double labeled with p73 (arrowheads in D′). Double immunostaining for reelin and GABA expression (E, E′) in the E19 MAM brain showed that the reelin-positive cells did not co-label with GABA (E, arrowheads in E′). Scale bars: low magnification = 130mm; high magnification = 40mm.