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. Author manuscript; available in PMC: 2011 Apr 7.
Published in final edited form as: J Theor Biol. 2009 Dec 23;263(3):385–392. doi: 10.1016/j.jtbi.2009.12.018

Figure 4. Critical condition of the transition to the low-virus steady state (or the oscillating state) after acute infection.

Figure 4

(A) Critical initial level of memory CTLs, Mc(0), required for the switch to the low-virus state or oscillating state, as a function of the initial helper cell level, HN(0)+HE(0). Cell levels are shown as percentage of CD4 T or CD8 T cell count in an average uninfected animal. (B) Decrease of the maximum virus load at the critical point, as compared to its value in a non-vaccinated animal. (A and B) The infectivity parameter ratio, pA/pR and identifiers of three unvaccinated animals from Ref. (Letvin et al., 2006), M-575 (blue), AC-04 (red), and 44-I (green), whose parameter sets were used for simulation (Table 1 and Appendix B), are shown in the legend. Solid lines with open squares: pA/pR=250. Dotted lines with other symbols: Other values of pA/pR, as shown.